Abstract
Summary
1. The plasma tide of AHF was measured after subcutaneous and intramuscular injections of bovine AHF fractions into hemophilic dogs. Better results were obtained with intramuscular than with subcutaneous administration; higher plasma AHF levels were maintained for longer times. Citrate in adequate concentration in the AHF solutions appeared to have an adjuvant action. 2. The rate of fall off of plasma AHF was followed after moderate levels of this clotting factor had been maintained for several hours. It is suggested that the biologic half-life of AHF in the dog may be at least 23 hours.
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