Abstract
Summary
Previous work has shown that a combined thyroxin-cortisone therapy in hypophysectomized rats will eliminate the anemia and induce a marked decrease in peripheral white cells; this was accompanied by severe hypoplasia of the bone marrow. It has also been shown that growth hormone increases peripheral white cell count in hypophysectomized rats but has no effect on peripheral anemia; the bone marrow was hyperplastic. Adding growth hormone to the thyroxin-cortisone therapy resulted in repair of post-hypophysectomy anemia, in normal histological appearance of bone marrow, in normal total number of cells/mm3 of marrow tissue, and in values for myeloid elements/mm3 of marrow and peripheral white cells slightly above normal. The values for erythroid elements/mm3 of marrow averaged 82% of normal. These hematological findings were accompanied by a normal oxygen consumption.
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