Abstract
Summary
When phenethyldiguanide (PEDG) is administered to guinea pigs, it produces hypoglycemia accompanied by depletion of liver glycogen with no increase in muscle glycogen. PEDG causes decreased blood urea formation and decreased non-protein nitrogen excretion in the urine. It also produces an early and significant rise in blood lactic acid. From studies made on surviving slices of guinea pig liver, it is evident that PEDG increases lactic acid formation and increases glycogen depletion, but it does not affect glucose output. PEDG also exerts an effect on isolated rat diaphragm, increasing glucose uptake, increasing lactic acid production, decreasing glycogen formation, and decreasing oxygen uptake.
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