Abstract
Summary and Conclusions
Stimulation of erythropoiesis in the sublethally irradiated or hypophysectomized rats was demonstrable following injection of a 3-fold concentrated acidified boiled extract of plasma from either rats exposed to simulated altitude or rabbits with phenylhydrazine-induced anemia. No relationship could be established between activity and coexisting liver disease in phenyl-hydrazine-treated animals. It was estimated that 70-90% of the erythropoietic activity was destroyed by heating acidified plasma at 100° for 10 minutes. Heating for 60 minutes did not further reduce activity. It is suggested that the small fraction of residual activity present after prolonged boiling does not warrant the designation of erythropoietine as a heat stable material nor does it necessitate the assumption of a separate heat stable component, although it does not entirely exclude this possibility.
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