Abstract
Summary
1. In 4 of 6 normal subjects, the intravenous injections of 0.03 mg of glucagon per kg body weight 2 1/2 hours after the ingestion of a standard fat breakfast caused a reduction of serum triglyceride concentration either toward or to the postabsorptive levels within half an hour. Of the 2 exceptions one failed to display any rise in concentration of triglycerides following the fat meal, prior to glucagon injection. The second failed to have a hyperglycemic response to glucagon. The rise in concentration of his serum triglycerides could be prevented by glucagon only when he was fed additional glucose with the fat meal. 2. Concentration of nonesterified fatty acids, measured in the sera of 2 subjects decreased following glucagon administration. 3. It was concluded that the effect of glucagon on serum lipids is secondary to its hyperglycemic effect.
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