Alteration of Hepatic Storage of Radiolabeled Vit. B 12 . ∗

Abstract

Summary

Radioactivity measurements were made over the liver, spleen and precordium for 7 1/2 months after oral administration of test doses of radioactive vit. B₁₂. One subject was given a large series of parenteral injections of nonradioactive vit. B₁₂, while another subject served as a control. The disappearance rate of radioactivity was much faster with the repeated parenteral injections. Radioactivity was lost in the urine. These observations showed that massive parenteral doses of vit. B₁₂ exchanged with cyanocobalamin stored in the liver.