Abstract
Summary
Homogenates of perfused rat, human and guinea pig livers agglutinate washed autologous red cells. The factor responsible for agglutination was partially purified and it appears to be a heat-stable phospholipid. Agglutination occurred in the cold, at room temperature and at 37°C. Lysis did not occur in the presence of complement. High dilutions of autologous serum completely inhibited hemagglutination. Agglutinating activity was high in liver, present in kidney and practically absent in spleen, lung and skeletal muscle. Rat liver preparations strongly agglutinated red cells of rat, rabbit and mouse, but not cells of dog, sheep, guinea pig or human. Human and guinea pig liver had much less autohemagglutinating activity than rat liver.
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