Abstract
Summary
Acid secretion and O2 uptake measured in frog gastric mucosae in vitrooccur but at reduced rates when Na in bathing solutions is .6 mM or less. Both are raised towards maximal when Na is 10 mM. Secretion occurs at 75% maximal when Li replaces Na. Adrenal cortical extract reduces secretion with high Na and has no effect with low Na. Neither added Ca nor Mg is necessary for secretion, but secretion is reversibly inhibited by 1 mM ethylenediaminetetraacetate. Secretion occurs when K is .3 mM but is maximum at 3 mM. Secretion occurs at 20% maximal when Cl is .2 mM or less. Secretion is unaffected by replacing Cl by Br, but it is reduced when Cl is replaced by I.
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