Abstract
Summary
As a general rule a fairly large percentage of total serum cholesterol rose to the surface when sera containing markedly elevated amounts of “readily extractable cholesterol” were centrifuged at 20.000 g for 2 hours. Sera having a normal “readily extractable cholesterol” concentration showed very little of the cholesterol rising to the surface under the same conditions. A few subjects, including most nephrotic patients studied, differed markedly from this pattern. In these cases, only a small amount of cholesterol rose to the surface during centrifugation in spite of the fact that the sera had markedly elevated “readily extractable cholesterol” concentrations. It is suggested that the cholesterol which rose to the surface is cholesterol which is associated with chylomicrons, while that which did not rise but which is a part of the “readily extractable cholesterol” is cholesterol present in lipomicrons.
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