Abstract
Summary
Pentobarbital and secobarbital were compared in equivalent doses in the mouse, rat, rabbit and dog. When given pentobarbital, female mice destroyed it faster, slept a shorter length of time, and woke at higher body levels than with secobarbital. Female rats showed no significant difference in sleeping times between these 2 drugs. Male rabbits and female dogs slept a shorter length of time and woke with higher plasma levels with pentobarbital than with secobarbital. There was no statistically significant difference in rate of destruction between these 2 drugs in these 2 species. In the mouse rate of destruction of both drugs was dependent on size of the dose, the higher the dose, the lower the rate of destruction. Pentobarbital and secobarbital had different dose-sleeping time response curves in mice, rabbits and dogs (but not rats).
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