Abstract
Summary
1. The effect of addition of testosterone (2mM) in vitroto liver, kidney and brain slices from intact and castrated rats treated with testosterone propionate and sesame oil in vivoand exposed to cold (2 ± 2°C) was studied in the Warburg constant volume respirometer. 2. No significant change was found in rate of oxygen uptake of liver slices with any treatment. These results with liver reflect a more rapid rate of destruction of testosterone. Kidney and brain slices from intact animals show a decrease in rate of oxygen uptake after addition of testosterone in vitro.Kidney and brain slices from untreated castrated rats kept at room temperature exhibit no change in rate of oxygen uptake after addition of testosterone in vitro.3. Tissue from castrated rats treated with sesame oil and maintained at room temperature or in cold show a decrease similar to tissues from intact animals following addition of testosterone in vitro.4. All changes were temporary and inhibitory, except in the case of animals treated with testosterone propionate in vivoat room temperature.
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