Abstract
Summary
Rabbit antisera to both rat kidney saline homogenate and the tryptic digest of rat kidney adsorbed on streptococci caused cytotoxic effects upon rat kidney cells in tissue culture as well as renal pathology in vivo following intravenous injection of rats. The titers of the cytotoxic effect in tissue culture paralleled the nephrotoxic effect in vivo and the anti-kidney hemagglutinin titers in vitro. The kidney cells grown in tissue culture tubes were effective in absorbing the potent nephrotoxic factor from serum. The cytotoxic effect of the nephrotoxic serum appears to be markedly species specific.
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