Abstract
Summary and conclusions
1. Topical application of several antihistaminic drugs to the mucosa of canine corpus pouches significantly inhibited the acid secretory responses of these pouches to parenterally administered histamine. One local anesthetic agent elicited similar inhibition. These inhibitory substances were effective also against a vagomimetic stimulant, urecholine. 2. In an effort to explain these phenomena, 3 possible modes of action of the antihistaminics present themselves: (1) a specific (antihistaminic) effect, (2) an atropine effect, (3) a local anesthetic effect. The evidence presently available does not as yet permit of any preference among these several hypotheses.
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