Production of Gastric Ulcers in Dogs on Protein Depletion Regime. ∗

Abstract

Summary

Dogs maintained in the anemic state by phlebotomy with intravenous injection of amounts of iron equivalent to that removed in hemoglobin and concomitantly fed a low protein diet, are quite rapidly depleted of their protein reserves and the circulating plasma proteins are markedly altered. Weight loss is invariably considerable. In these animals the incidence of peptic ulcer is extremely high with a large percentage developing perforating ulcers causing death.