Properdin System and Nonspecific Inhibitor of Hyaluronidase. ∗

Abstract

Summary

The non-specific hyaluronidase inhibitor of serum (NSI) is not inactivated when serum is incubated with zymosan for 90 min at 37°C. Serum depleted of NSI does not lose complement activity. Thus it is unlikely that NSI is one of the known components of the properdin system. However, injection of lipopolysaccharides which increase the serum titre of properdin increases the titre of NSI.

1. The incidence of “spontaneous” convulsions and of convulsive deaths in C₃H male mice is greatly reduced by caloric restriction or by supplement of vit. B₁₂ in the diet fed ad libitum. Substitution of hydrogenated vegetable fat for lard decreased the age of onset of convulsions and increased the incidence of convulsive deaths. 2. Studies with auditory and electric stimulation appear to confirm the existence of a difference between the effect of HVF and of lard.