Evidence on Inheritance of Muscular Dystrophy in an Inbred Strain of Mice Using Ovarian Transplantation. ∗

Abstract

Summary

1. Critical evidence is given which supports the hypothesis that dystrophia muscularis is inherited in strain 129 mice on a unit autosomal recessive basis. 2. Offspring were obtained from ovaries of dystrophic females transplanted to histocompatible normal hosts. The incidence of dystrophy in a large F₂ population descended from these grafted ovaries is 19%. and in a large backcross population 44%. 3. Approximately 70% of the animals bearing ovarian grafts yielded graft offspring. The technic of ovarian transplantation, as modified from that of Robertson is described. 4. Using offspring of known genotype derived from transplanted ovaries, it has been possible to provide a reliable and extensive supply of dystrophic animals and normal littermates for research use.