Abstract
Summary and Conclusions
Infarcts of spleen and kidney were produced by vascular ligation in 13 dogs. The level of serum alkaline phosphatase increased significantly in 3 of 6 dogs with splenic infarcts and in 6 of 7 with renal infarcts. The level reached a maximum in about 24 hours and gradually returned to normal in about a week. An increase in serum alkaline phosphatase level was noted also in dogs with experimental endocarditis. This increase correlated well with the occurrence of infarcts in spleen and kidneys and proved to be of great diagnostic and prognostic value.
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