Abstract
Summary
1. The present studies have shown that, in addition, significant loss of kidney function can result from exposure to this material. Such kidney debilitation could be of considerable consequence if it occurred together with severe liver damage. The time of occurrence of maximal kidney effects correlates well with time of death after NNDMA. as well as with that of rise of blood NPN in rabbits and in dogs. 2. No histologically demonstrable changes in functional kidney cells were evident in these animals nor in those examined by other investigators (3,4). However, other investigators found local vascular congestions in liver, lungs and intestine. The present experiments indicate this to be true in kidneys which show significant loss of function. The suggestion(3) that an outstanding property of NNDMA is its affinity for vasculatures of liver, lung and intestine may also apply to vasculature of kidney.
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