Antibacterial Properties of Orinase in Infected Mice

Abstract

Summary

1. The chemotherapeutic properties of 2 newly discovered sulfonamide antidiabetic agents have been studied in infected mice and compared to a commonly used triple sulfa mixture. Data demonstrating that 1-(p-methylphenylsulfonyl)-3-butylurea is devoid of any antibacterial activity and that 1-(p-aminophenylsulfonyl)-3-butylurea is active as an antibacterial agent have been presented. Lack of antibacterial activity of 1-(p-methylphenylsulfonyl)-3-butylurea can be attributed to absence of the para-amino group. This para-amino group is present in each of the ingredients in the triple sulfa mixture as well as other sulfanilamide-like compounds. 2. It has been demonstrated that failure of 1 - (p-methylphenylsulfonyl)-3 - butylurea to protect infected mice was due to a true lack of antibacterial activity, and death of test animals was not attributed to toxicity. 3. Large daily doses of 1-(p-methylphenylsulfonyl)-3-butylurea have been shown not to interfere with therapeutic activity of tetracycline in infected mice.