Abstract
Summary
Reversal of hyaluronidase effects on concentration of negatively charged colloids in the dermis of normal and cortisone treated rabbits was studied by serial measurement of liquid junction potentials. In normal animals, hyaluronidase lowers negative charge density in the tissues; recovery is half completed in about 4 hours. In animals treated with cortisone initial charge density is lower than in normal animals. After hyaluronidase is injected into the dermis, the lowest levels are reached. Half recovery, however, occurs in 2 1/2 hours. Serial electrometric measurements following hyaluronidase injection are suggested as a means of studying hormone and drug effects, and disease states in connective tissue.
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