Abstract
Summary
1. Progestational activity of a series of 17-substituted 19-nortestosterone derivatives was investigated using both intrauterine and systemic assays in rabbits. Several of the substances studied possessed a high order of progestational activity. This activity was not related to either androgenic or anabolic potency of these compounds. Of the compounds studied 17-butenyl appeared to be the most potent, possessing about 10 times and 2 1/2 times the activity of progesterone in intrauterine and systemic assays, respectively. 2. Progesterone-like activity of these 19-nortestosterones was further demonstrated by the ability of some members of the series to maintain pregnancy in ovariectomized rabbits.
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