Abstract
Summary
A new intestinal antipropulsive test in intact insulin-treated rat is described. The insulin test provides certain advantages over the commonly-used charcoal meal test for screening of synthetic antispasmodic or antipropulsive agents. The use of both tests permits determination of the effect of the agent on both normal and hyperactive states of intestinal muscle and provides information relative to the mechanism of action of the agent. The specificity and some limitations of the test are discussed.
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