Abstract
Summary
The adrenalectomized rat may exhibit a normal hyperglycemic response to trauma if maintained with a constant dose of glucocorticoids while fasting or if untreated but fed. In both cases the normal response is interpreted as being dependent on an availability of liver glycogen to permit an hyperglycemic response while the failure of the fasted untreated adrenalectomized rat to develop hyperglycemia may be due to deficient glycogen stores rather than to hormone lack per se. The significance of these findings is discussed in relation to current concepts of the interaction of the adrenal cortex and the stress reaction.
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