Abstract
Summary
Two strains of Japanese B encephalitis virus have been serially propagated in tissue cultures of chick embryo fibroblasts (both plasma-clot explants and trypsinized cells), monkey kidney epithelium. HeLa cells, and Detroit-6 cells. Cytopathogenicity, which was consistent and reproducible, was observed only with the Detroit-6 cells. Maximal virus growth and release was observed 2 days before CPE became pronounced. This effect was readily neutralized by JBE immune serum. A similar CPE has been observed in Detroit-6 cells infected with the Egypt 101 strain of West Nile virus.
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