Abstract
Summary and Conclusion
The data in our study indicate that estrogenic hormones exert a protective action against the toxic effects of digoxin on the myocardium. Male dogs and castrate female dogs have been found to be highly sensitive to toxic manifestations of a cardiac glycoside on cardiac rhythm, in comparison with normal females in anestrus, or castrate females treated with estrogenic substance. A high degree of resistance to toxicity of digoxin was exhibited by the 3 normal females in natural estrus which were available.
Get full access to this article
View all access options for this article.