Abstract
Summary
Seven mouse strains which were selected for the wide range in their natural resistance to S. typhimurium were used. Typhoid resistance of every strain was decreased when 1 mg cortisone was given one day before typhoid inoculation. The difference between survival of cortisone treated mice and that of controls was evident at an earlier time in the genetically susceptible strains than in resistant strains. A single injection of 5 mg cortisone which reduced survival of non-immunized mice from 100% to 0% had no significant effect on survival of immunized mice.
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