Abstract
Conclusion
1. The therapeutic effectiveness of very large doses of tetanus antitoxin is markedly reduced by simultaneous administration of cortisone, when both agents are given 24 hours after injection of toxin. 2. Administration of steroid has little or no effect on the course of experimental tetanus if administration of antitoxin is delayed 48 or more hours after exposure to toxin. 3. Cortisone increases the activity of tetanus toxin. 4. Results suggest strongly that the use of cortisone in addition to antitoxin for treatment of human tetanus may produce a deleterious effect.
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