Abstract
Summary
1. Seventeen of 42 patients wrho received tetrahydrozoline intravenously exhibited an immediate pressor response which lasted an average of 12 minutes. Twenty-five minutes following the initial injection hypotension ensued, lasting an average of 3 hours. The pressor phase was characterized by a decrease in cardiac output, bradycardia and an increase in total peripheral resistance. The hypotensive phase was characterized by no change in cardiac output, less bradycardia than in the pressor phase, and a decrease in peripheral resistance. 2. When tetrahydrozoline was administered orally, no pressor response was noted. Twenty-seven of 34 patients exhibited an average reduction of 44 mm Hg systolic pressure, 25 mm Hg diastolic pressure, and an average decrease in heart rate of 20 beats per minute. Tolerance usually developed in 7 to 10 weeks.
Get full access to this article
View all access options for this article.