Abstract
Summary
1. The in vivo effects of CoA, ATP, AMP, CMP and oxalacetate on lipide phosphorylation in the liver of rats have been investigated in choline deficient rats. 2. A single dose of coenzyme A stimulates phospholipide synthesis in choline and in pantothenic deficient animals; oxalacetate stimulates in choline deficient animals. 3. Administration of a single dose of a mixture of CoA, AMP, oxalacetate and choline stimulates lipide phosphorylation in both mitochondria and nuclei greater than choline or saline alone. The greatest stimulation occurred in the lecithin fraction. 4. Cytidine monophosphate stimulates lipide phosphorylation. There is further stimulation when CMP is administered with AMP, oxalacetate and choline.
Get full access to this article
View all access options for this article.