Abstract
Summary
Evidence has been obtained employing C14 tracer technics which shows no appreciable conversion of 2-keto-L-gulonic acid to L-ascorbic acid by the rat or guinea pig. From these results it is suggested that the most likely intermediate in the conversion of L-gulonolactone to L-ascorbic acid by the rat is 2-keto- or 3-keto-L-gulonolactone. In addition it was found that the major part of the administered 2-keto-L-gulonic acid was excreted unchanged in the urine.
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