Abstract
Summary
(1) Addition of 9-a FF in a concentration of 0.5-1.0 μg/ml results in a positive inotropic action, an increased uptake of intramuscular Na and loss of K. (2) In a concentration of 10-20 μg/ml, 9-a FF gives rise to a negative inotropic action, loss of intramuscular Na and an increased uptake of K. (3) Employing the isolated heart preparation, addition of 0.5 μg/ml of 9-a FF to the failing heart results in a partial recovery. Conversely, 10 μg/ml added to the ‘normal’ heart brings about failure quite rapidly. (4) A histological correlation of the reported results is shown. (5) The mechanism of action and significance are discussed.
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