Abstract
Summary
1. The clinical effects of specially purified streptokinase preparations have been determined in man. Streptokinase, 6-7 fold purer than that previously available, has been shown to have a greatly diminished toxicity, when administered by the intravenous route. The best of these preparations have only 1/20th of the toxicity of the previous preparations. 2. Systemic fibrinolysis has been induced in man by infusion of these preparations, unprotected by reaction suppressing drugs. A comparison between those patients who showed peripheral blood fibrinolysis, and those who did not, indicated that this state is asymptomatic in the human. 3. 165 electrocardiograms taken on 60 patients, before, during and after the infusion of streptokinase showed few changes and these were of minor degree. Since they followed no consistent pattern it was not posible to ascribe the changes to the effect of the infusion.
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