Comparative Metabolism of Sr 89 and Ca 45 by Bone Grown in vitro. ∗

Abstract

Summary

An in vitro culturing technic was used in comparing metabolism of calcium-45 and strontium-89 in bone. The results of a large number of determinations indicated: a) that at 2 hrs bone contained 1.08 times as much strontium-89 as calcium-45; b) when exposed to constant levels of Sr⁸⁹ and Ca⁴⁵, the Observed Ratio_bone-medium equilibrated at 0.83 within 7 days; c) strontium-89 was released from bone at a ratio of about 1.2 times that of calcium-45; d) addition of carrier strontium markedly inhibited the long term deposition of calcium in bone but the discriminatory mechanisms were unaltered.