Abstract
Summary
DON affects adversely the fetus when given from time of implantation to mid-term, and two doses of .5 mg/kg during this time will result in complete litter destruction. The action of DON appears to be directly on the fetus and not on placenta, ovary or pituitary. Progesterone given prior to DON administration did not protect the litters. Large doses of adenine sulfate given prior to DON administration protected the litters to a large degree. Repeated complete litter destruction in the same animals gave no evidence of cumulative toxicity, nor did DON adversely affect the fertility of the mother rats, or subsequent offspring.
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