Abstract
Summary
The ability of a mixture of SK and human plasminogen to activate bovine plasminogen was shown to be dependent upon the concentrations of both components. The ‘activator' which was formed, may deteriorate on incubation even though the SK and human plasminogen when incubated separately were stable. The decrease was partially or completely restored by the addition of SK. The rate of disappearance of the ‘activator' was affected by the plasminogen preparation and by the initial SK concentration. The in-activation occurred at physiological pH as well as at pH 6.4. The in vitro and in vivo significance of the data were discussed.
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