Abstract
Summary
1. Twenty-five compounds representing structural derivatives of benzoic acid were studied with regard to their effects on circulating 17-hydroxycorticosteroid (17-OHCS) concentrations in guinea pigs. 2. Benzoic acid had no effect on these concentrations. 3. Among the monohydroxybenzoic acids, the o- and m-substituted derivatives produced elevated plasma 17-OHCS concentrations. The latter compound exerted its effect earlier following administration than did salicylate. p-Hydroxybenzoate had no significant effect. 4. Among the mono-ether derivatives of benzoic acid only the o-substituted compounds produced significant elevations of plasma 17-OHCS concentrations. Significant elevations were produced by 3, 4, 5-trimethoxybenzoic acid. 5. Both o- and paminobenzoic acid produced steroid elevations of borderline significance. 6. The addition to the salicylate structure of a second hydroxyl group in the 3 or 6 position or of an ether group in the 3 position appeared to augment the effect on 17-OHCS concentrations. 7. Aspirin exerted the greatest effect on plasma 17-OHCS concentrations of any compound tested. 8. The salicylate metabolite, salicyluric acid, had no effect. 9. A comparison of the influence of these compounds on 17-OHCS concentrations with antirheumatic and anti-inflammatory properties and with effects on adrenal ascorbic acid concentrations, as reported by others, was attempted.
Get full access to this article
View all access options for this article.