Abstract
Summary
The feeding of large doses of nicarbazin to calves produced moderate nephrotoxicity associated with precipitation of crystalline deposits in the renal tubules. These crystals were identified as 4, 4′-bisacetamidocarbanilide. Additional evidence is presented that, after absorption, nicarbazin splits into its components, dinitrocarbanilide and hydroxydimethylpyrimidine, which are metabolized separately. The dinitrocarbanilide is first reduced to soluble diaminocarbanilide and then acetylated to insoluble 4,4′-bisacetamidocarbanilide. The renal tissue reaction and the metabolic degradation of 4,4′-dinitrocarbanilide resembles that known for the sulfonamides.
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