Abstract
Summary
1. Quinidine sulfate at a concentration of 1 × 10-3 M strongly inhibits the uptake of glucose and fructose by intact rat diaphragm under anaerobic conditions. 2. Quinidine is without effect on endogenous anaerobic lactic acid production by rat diaphragm. 3. Glucose at a concentration of 1 mg/ml or 4 mg/ml markedly stimulates anaerobic glycolysis while fructose at a concentration of 5 mg/ml produces only a slight stimulation. 4. Stimulation of glycolysis by glucose or fructose is abolished by 1 × 10-3 M quinidine and partially inhibited by 5 × 10-4 M quinidine. 5. It is suggested that quinidine inhibits glucose or fructose uptake prior to the step at which these sugars and glycogen share a common metabolic pathway.
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