Abstract
Summary
The toxicity of 5-bromouracil has been studied in mice, rats and dogs. Single lethal doses in rodents caused death with-in 12 to 24 hours. Somewhat smaller amounts when given repeatedly in daily doses gave rise to crystals in the kidney. These have been shown by chromatographic and spectrophoto-metric methods to be predominantly unchanged 5-bromouracil. The urines of rats given a single high dose of the compound have been found to contain uracil and 5-bromouracil. In dogs deaths are produced by the oral administration of 0.5 to 1.0 g/kg daily excepting weekends for a total of 10 doses. The principal changes noted in fatally intoxicated dogs were weight loss, anorexia, diarrhea and significant concentrations of bromide ion in plasma. In one such animal, the bladder with filled with a deposit of 5-bromouracil.
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