Effect of X-Ray Dose on Mortality and Skin Transplantability in Mice Receiving F 1 Hybrid Marrow. ∗

Abstract

Summary

The 21-day LD₅₀ under the conditions of X-irradiation used is approximately 600 r. Irradiation of CBA mice followed by intravenous administration of bone marrow suspension from Cb x CBA F₁ hybrids resulted in little or no 21-day mortality at 110, 330, 660 and 770 r, but in almost 100% mortality at 550 r. Homografts of Cb skin into the surviving mice were accepted by the mice at 660 and 770 r dose levels but not by mice at 0, 110 and 330 r dose levels. None of the marrow-treated mice at 550 r survived long enough to be skin grafted.