Relation of Endocrines and Clearing Factor Inhibitors to Hyperlipemia in Fasted Animals. ∗ †

Abstract

Summary

1. LM produced hyperlipemia only in animals primed for lipid mobilization. 2. Intravenous injection of toxic doses of protamine sulfate, convulsant doses of diisopro-pylfluorophosphate and pyrogenic doses of piromen produced hyperlipemia in intact animals. 3. The same doses of these substances injected into adrenalectomized and hypophy-sectomized rats did not produce hyperlipemia.

4. The hyperlipemic action of protamine or DFP is not attributable to direct inhibition of lipoprotein lipase but to a secondary effect mediated through the adrenals and pituitary.

5. The hyperlipemic action of protamine, DFP, pyrogens and possibly other stressors is best explained by release of LM.