Abstract
Summary
Digoxin in a dose of 0.2 mg/ kg caused either no change or a slight increase in the cardiac glycogen fractions when administered to rats of 30 days of age or less, but caused a decrease in all fractions of cardiac glycogen when given to rats of 100 and 360 days of age. At 630 days of age, digoxin caused a fall in the trichloroacetic acid soluble fraction and an increase in the acid insoluble fraction with no change in total cardiac glycogen. When administered to 100- and 360-day-old rats toxic doses of digoxin increased all fractions of cardiac glycogen except the acid soluble fraction of the 100-day-old rats which showed no change.
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