Abstract
Summary
The effect of chlortetracycline-HC1 on the isolated rat heart is practically identical with the effect of a known chelating agent, tetrasodium versenate. This effect can be reversed temporarily by Mn++. Thus, chlortetracycline seems to cause irregularities in the isolated rat heart by chelation of the co-factor of cholinesterase which inactivates this enzyme and permits acetylcholine to accumulate and to exert its inhibitory effect on the heart. The co-factor of cardiac cholines-terase may be Mn++.
Get full access to this article
View all access options for this article.