Abstract
Summary
A comparison has been made of the ability of 4 different pertussis antigens to produce a booster antibody response. Using increase of mouse protective antibody as measured by intranasal challenge as the criterion, excellent results were obtained with both soluble antigen and hemagglutinin. An explanation of the findings with the latter antigen is discussed.
We gratefully acknowledge the cooperation of Dr. Harold H. Berman and Dr. Martin Lazar of the Willowbrook State School in planning and carrying out this study. We also wish to thank Dr. Robert Ward and Dr. L. Emmett Holt. Jr., of this department, for their help and encouragement. Loretta Brown gave excellent technical assistance.
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