Abstract
Summary
1. The relative effectiveness of live and killed H. pertussis vaccine has been studied in children. 2. By means of a passive mouse protection test, using the intra-nasal route of challenge, a more rapid loss of antibody after primary immunization and a greater booster response was observed with live vaccine. 3. Severe local reactions occurred in some children given the live vaccine.
We gratefully acknowledge the cooperation of Dr.
Harold H. Berman and Dr. Martin Lazar of the Willowbrook State School in planning and carrying out this study. We wish to thank Dr. Robert Ward and Dr. L. Emmett Holt, Jr. of this department for their continued help and encouragement. Loretta Brown gave excellent technical assistance.
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