Abstract
Summary
1) High complement fixation titers with PPD-S were obtained with BCG antisera which showed high precipitating antibodies to PPD-S and to tuberculo-polysac-charide. 2) Polysaccharide fixed no complement even in these sera when incubation was carried out at 37°C. However, at 4°C fixation did take place. 3) When polysaccharide was mixed with PPD-S the complement-fixation titer was decreased from that obtained with the PPD-S alone, suggesting inhibition of fixation at 37°C. However, this decrease appeared to be due to fixation by polysaccharide in the first stage, followed by a probable release of the complement to the red-blood-cell-amboceptor system in the second stage.
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