Synthesis of Diphosphopyridine Nucleotide by the Livers of Mice Bearing Transplantable Tumors. ∗

Abstract

Summary

1. Homogenates of liver from mice bearing transplanted tumors (Sarcoma 37, Lymphoma 1, Lymphoma 2, Leukemia L 1210, Hepatoma 129 and Leukemia L-4946) exhibited a drop of 30 to 50% in capacity to synthesize DPN. 2. Surgical removal of Sarcoma 37 restored the DPN-synthesizing capacity of the livers to the level of livers from control mice. 3. Within one day after inoculation of tumor into mice, ability of the blood to synthesize DPN dropped about 50%.