Abstract
Summary
‘Valmid’, a new nonbarbituric hypnotic, has been compared with ‘Seconal Sodium’, urethane, and a convulsant barbiturate with respect to its ability to inhibit normal and potassium-stimulated respiration of rat brain cortex slices in vitro. In concentrations equivalent to those obtained during anesthesia, only ‘Seconal Sodium’ depressed the oxygen uptake of normal tissue whereas both ‘Seconal Sodium’ and ‘Valmid’ inhibited the respiration of KCl-stimulated tissue.
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