Abstract
Summary and Conclusions
Chronic treatment with tolerated doses of 6-mercaptopur-ine causes a reduction of 50% or more in the respiration and anaerobic glycolysis of Sarcoma 180 while it does not impair the metabolic functions in liver and kidney. Succinic dehydrogenase activity of Sarcoma 180 is also impaired by treatment with 6-mercaptopurine, but this effect does not seem to be great enough to account fully for the observed reduction in respiration.
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