Abstract
Summary
(1) A mammalian tumor-inducing virus, that of the Shope fibroma, has been propagated in tissue culture. (2) Two lines of fibroma virus were each carried through 14 successive passages in tissue cultures of cottontail testes. (3) One line of virus was carried up to 4 passages in similar cultures of domestic rabbit testes. (4) Growth of virus was accompanied by formation of acidophilic, intracytoplasmic inclusions and by vacuoles containing a substance with a ground glass appearance.
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